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Berberine as one of the Metformin Alternatives

The incidence of insulin resistance, obesity, and other metabolic disorders have reached massive proportions in industrialized nations. Currently, one of the more popular glucose-lowering drugs available by prescription is metformin. This drug comes with potential side effects, some of which are very serious.

Research suggests it has powerful blood-sugar-lowering effects and may be as effective as various conventional type 2 diabetes medications therefore, we are going to talk about berberine health benefits and what it actually does as a natural alternative to metformin.

WHAT IS BERBERINE ?

Berberine is a bioactive compound that can be extracted from several different plants, including a group of shrubs called Berberis17.

Technically, it belongs to a class of compounds called alkaloids. It has a yellow color, and has often been used as a dye.

Berberine has a long history of use in traditional Chinese medicine, where it was used in Ayurvedic and Traditional Chinese Medicine to treat health issues like infections. Now, modern science has confirmed that it has impressive benefits for several different health problems.18

HOW DOES BERBERINE WORK ?

Berberine has now been tested in hundreds of different studies. It has been shown to have powerful effects on many different biological systems.19

After you topically apply our Berberine, it is taken in by the body and transported into the bloodstream. Then it travels into the body’s cells. Inside the cells, it binds to several different “molecular targets” and changes their function.20

One of the main actions of berberine is to activate an enzyme inside cells called AMP-activated protein kinase (AMPK).21

This enzyme is sometimes referred to as a “metabolic master switch”.22

It is found in the cells of various organs, including the brain, muscle, kidney, heart and liver. This enzyme plays a major role in regulating metabolism.23, 24

Berberine also affects various other molecules inside cells, and may even affect which genes are turned on or off.25

 

OTHER HEALTH BENEFITS OF BERBERINE:

  • Depression:Rat studies show that it may help fight depression.26, 27, 28
  • Cancer: Test tube and animal studies have shown that it can reduce the growth and spread of various different types of cancer.29, 30
  • Antioxidant and anti-inflammatory: It has been shown to have potent antioxidant and anti-inflammatory effects in some studies.31, 32, 33
  • Infections: It has been shown to fight harmful microorganisms, including bacteria, viruses, fungi and parasites.34, 35, 36, 37
  • Fatty liver: It can reduce fat build-up in the liver, which should help protect against non-alcoholic fatty liver disease (NAFLD).38, 39
  • Heart failure: One study showed that it drastically improved symptoms and reduced risk of death in heart failure patients.40

FINAL THOUGHTS:

Berberine is a good natural substance for reducing blood sugar levels and increasing insulin cellular sensitivity with relatively few side effects. It has demonstrated quite a few numbers of positive health benefits outside of its anti-diabetic and cholesterol-lowering properties. This plant-based phytonutrient is touted in multiple scientific studies as a natural alternative to metformin and other drug substances that decrease blood sugar levels.  If you’re currently taking any medications, it’s important to speak with your doctor or healthcare provider before taking berberine due to the risk of interactions and lowering blood sugar levels.

References:

17 https://www.naturalmedicinejournal.com/journal/2012-12/clinical-applications-berberine

18  https://pubmed.ncbi.nlm.nih.gov/25498346/

19 https://pubmed.ncbi.nlm.nih.gov/22842630/

20 https://pubmed.ncbi.nlm.nih.gov/24174332/

21 https://diabetes.diabetesjournals.org/content/55/8/2256.full

22 https://pubmed.ncbi.nlm.nih.gov/10409121/

23 https://pubmed.ncbi.nlm.nih.gov/8557660/

24 https://www.ahajournals.org/doi/full/10.1161/01.res.0000256090.42690.05

25 https://pubmed.ncbi.nlm.nih.gov/24174332/

26 https://pubmed.ncbi.nlm.nih.gov/18585703/

27 https://pubmed.ncbi.nlm.nih.gov/17804020/

28 https://pubmed.ncbi.nlm.nih.gov/18955248/

29 https://journals.lww.com/anti-cancerdrugs/Abstract/2009/10000/A_systematic_review_of_the_anticancer_properties.1.aspx

30 https://pubmed.ncbi.nlm.nih.gov/25153862/

31 https://www.hindawi.com/journals/ecam/2014/289264/

32 https://pubmed.ncbi.nlm.nih.gov/21110076/

33 https://pubmed.ncbi.nlm.nih.gov/23087140/

34 https://pubmed.ncbi.nlm.nih.gov/12422513/

35 https://pubmed.ncbi.nlm.nih.gov/21660679/

36 https://pubmed.ncbi.nlm.nih.gov/16379555/

37 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104554

38 https://www.hindawi.com/journals/ecam/2013/308134/

39 https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0383-6

40 https://pubmed.ncbi.nlm.nih.gov/12860219/

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